The “Devil’s Eyes” of HeLa Cells captured with the A1R became the famous icon of 2011-12 One-Book-One-Northwestern event, wherein Rebecca Skloot’s “The Immortal Life of Henrietta Lacks” was the featured book.
(Red) Actin; (Green) Microtubule; (Blue) DAPI
Comparison of N-Sim to conventional microscopy
Comparison of optical resolution achieved using conventional confocal (left) and Nikon SIM structured illumination super-resolution microscope (right). Note that the SIM system successfully resolved the double globular heads of myosin II (red arrows) along stress fibers.
Photoconversion of Kaede-tagged myosin light chain kinase in PTK-2 cells. This technique allow users to directly track the kinetics of the converted pool of molecules.
Photomanipulation techniques such as this can be performed on the Nikon A1R or the Andor-Nikon Yokogawa spinning disk confocal systems.
Platinum Replica of cytoskeleton
Platinum replica TEM of endothelial cells showing intricate actin cytosksletal network under the cytoplasm.
Non-linear second harmonic generation to detect anisotropic structures, the A1R-MP is also equipped with backward scattered and forward propagated second harmonic waves to image label-free collagen, as well as myofibrils in situ. Green channel is fluorescence, blue channel is second harmonic generation by collagen I in the skin of mice.